The Big E, the only cross-state agricultural fair in the United States
The Big E Coliseum, a 5,900-seat multi-purpose arena in West Springfield, Massachusetts
Elvin Hayes (born 1945; nicknamed "Big E"), retired American basketball player and radio analyst
USS Enterprise (CV-6) (nicknamed "Big E"), the sixth aircraft carrier of the United States Navy
USS Enterprise (CVN-65) (nicknamed "Big E"), the world's first nuclear-powered aircraft carrier
Eric Lindros (born 1973; nicknamed "Big E"), retired Canadian professional ice hockey player
Eyjafjallajökull, the ice cap covering the stratovolcano known as "Big E"
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